Here, Gru has settled into a somewhat normal life with his adopted daughters as he manufactures jams and jellies, but it is easy to see that while he can give into the normalcy of his life, others can not. Dr. Nefario, his assistant has decided to move on to better opportunities, leaving Gru behind. It is at this time, that Gru discovers his life is not quite as complete as he had hoped as his daughters and a pushy neighbor have decided to help push him into the dating scene, with some rather strange results. Along comes Lucy Wilde, an agent for the anti-villain league who has orders to bring in Gru to recruit his help when a top secret lab and the serum they were working on goes missing. Gru reluctantly agrees and they find their hunting ground is the nearby mall. In the meantime, someone is kidnapping the minions and turning them into unstoppable monsters. Gru recognizes El Macho, a villain thought dead and soon discovers how fathers feel about their daughters dating for the first time when Margo discovers Antonio-who just happens to be the son of the villain they are seeking. Lucy discovers that Gru is the person she has come to love, and Doctor Nefario has to decide between his new job--and family when Gru steps in to save Lucy--and his minions from the notorious El Macho.