- File Size: 21377 KB
- Print Length: 459 pages
- Publisher: Atria Books; 1 edition (September 10, 2019)
- Publication Date: September 10, 2019
- Sold by: Simon and Schuster Digital Sales Inc
- Language: English
- ASIN: B07N4C6LGR
- Text-to-Speech: Enabled
- Word Wise: Enabled
- Lending: Not Enabled
- Amazon Best Sellers Rank: #1,642 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
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“Lifespan is entertaining and fast-paced—a whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters (‘The Demented Pianist’, ‘A Better Pill to Swallow’), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point.” (Nature Journal)
“Sinclair’s work on slowing the aging process, and even reversing some aspects of it, could lead to the most significant set of medical breakthroughs since the discovery of antibiotics nearly a century ago.” (Sydney Morning Herald)
"In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply." (Siddhartha Mukherjee, Pulitzer Prize–winning and #1 New York Times bestselling author )
“There are few books that have ever made me think about science in a fundamentally new way. David Sinclair’s book did that for me on aging. This is a book that anyone who ages must read.” (Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and co-author of Code of Codes )
“If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclair’s new book Lifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant.” (Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author )
“This is the most visionary book about aging I have ever read. Seize the day—and seize this book!” (Dean Ornish, MD, founder and president of the Preventative Medicine Research Institute and New York Times bestselling author of UnDo It! )
“In Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read.” (William W. Li, MD, New York Times bestselling author of Eat to Beat Disease )
“For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read.” (Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimer's )
“A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer.” (Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure )
“Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity.” (Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet )
“Imagine a world in which we can live long enough to meet not just our grandchildren, but our great-grandchildren. This is Sinclair’s vision for the future of humankind, a vision that looks to science, nature, history, and even politics to make the case that it is possible to live well into our hundreds. Lifespan is boldly leading the way.” (Jason Fung, MD, author of The Diabetes Code and The Obesity Code )
“I have had the pleasure of knowing Dr. David Sinclair and following his groundbreaking research into the causes and reversal of aging for many years. In Lifespan, David takes us on an entertainingly wild ride into both the author’s fascinating personal journey of discovery and his seminal research into why we age. But more importantly, he provides us with the everyday tools that we can all use to stop what he now calls ‘the disease of aging.’. . . You owe it to yourself and your loved ones to read and follow his advice, as I have for the last 15 years!” (Steven R Gundry, MD, New York Times bestselling author of The Longevity Paradox and medical director of the International Heart and Lung Institute )
“David Sinclair masterfully presents a bold vision of the future in which humanity is able to slow or reverse the aging process and live younger, healthier lives for longer. He engages the reader in a thorough examination of the science and emerging technologies that will enable humanity to achieve this vision.” (Victor J. Dzau, MD, president of the US National Academy of Medicine and CEO of Duke University Medical Center )
“Lifespan is the book we have been waiting for. It transcends everything we know about aging and longevity—a combination of brilliant scientific work, a pioneering mind, and the dream for a longer, healthier and happier life. Lifespan provides a vision for our future and the roadmap on how to get there, merging scientific breakthroughs and simple lifestyle changes to not only help us feel younger, but actually become younger.” (Naomi Whittel, New York Times bestselling author of Glow15 )
“I have written about the brilliant work of David Sinclair for over fifteen years and have watched his life’s mission of using science to slow the scourge of old age and dying move from the outer edge to more mainstream biology (he’s still pushing boundaries!) as his careful work in the lab has steadily shed light on how the mechanisms of aging work in humans and in other organisms. In Lifespan, the full force of his optimism, humor, and soft-spoken eloquence as a storyteller-scientist come through. I was charmed and delighted by his skill at blending his own life’s narrative and others’ with clear and levelheaded explanations of some very complex and emerging science. I’m hoping we have David Sinclair with us and doing his science and writing books for another 500 years, give or take a century.” (David Ewing Duncan, award-winning journalist, bestselling author, and curator of Arc Fusion )
“Lifespan gives us hope for an extraordinary life. As the brilliant Dr. David Sinclair explains, aging is a disease, and that disease is treatable. This eye-opening book takes you to frontlines of incredible breakthroughs. What could be more valuable than an extended health lifespan? Enjoy this must read masterpiece!” (Peter H. Diamandis, MD, New York Times bestselling author of Abundance and Bold )
“David is a pioneer poised to change how we think about and understand aging.” (Stephanie Lederman, CEO of the American Federation for Aging Research (AFAR), New York )
“The most important message and priority of our time. For years to come, humanity will reflect on this book with awe and respect. Read it. . . . Your life depends on it.” (Marc Hodosh, former owner & co-creator of TEDMED )
“A tour de force. Sinclair’s book, and his life’s work ranks with humanity’s greatest contributions to helping enhance the joy and happiness of life, ranking with the works of Jenner, Pasteur, Salk, Locke, Gandhi, and Edison. Lifespan is a groundbreaking literary triptych that expertly combines the science of living longer, a practical checklist to unleash our inner potential for healthy longevity, and a brilliant philosophical, policy and ethical synthesis. A masterpiece.” (Martine Rothblatt, founder, Chairwoman of the Board, and CEO of United Therapeutics and creator of SiriusXM Satellite Radio )
“Stepping on the moon changed humanity. In Lifespan, Sinclair takes the ultimate step for humanity that will transform our lives beyond anything we could ever have imagined. If you can put your deepest beliefs aside, this will be the most important book you will ever read. The author is bold, the science is profound, and our future is here.” (Henry Markram, PhD, professor at EPFL, Switzerland, director of the Blue Brain Project, and founder of Frontiers open-access journals )
“An intellectually fascinating book with tantalizing insights on the most important issue about yours and everyone’s future.” (Andrew Scott, PhD, professor of economics at London Business School and author of The 100-Year Life )
“Throughout the book, the author’s enthusiasm jumps off the page.” (Kirkus Reviews)
“Sinclair’s dedication to understanding aging on both a microscopic and global scale is bound to shatter centuries of paradigms.” (Scientific Inquirer)
“The book, which surpasses everything we know about aging and life extension, has been written with a rich literary material of impressive depth and clarity to offer a deeper understanding of genetics and human longevity research.” (Wall Street Pit)
About the Author
Matthew LaPlante is an associate professor of journalistic writing at Utah State University, where he teaches news reporting and feature writing. A former US Navy intelligence specialist and Middle East war correspondent, he is the author of Superlative: The Biology of Extremes and the cowriter of multiple other books on the intersection of science and society. He lives in Salt Lake City and skis in Big Cottonwood Canyon. To learn more, visit MDLaPlante.com and follow him on Twitter @MDLaPlante.
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Although this is plenty technical, it’s not an academic tome. Anyone, researcher or layman alike, will be able to follow the story thanks to the inclusion of so many personal accounts and reflections. After finishing, you will have a new perspective and hopefully realize that we have the ability right now to extend healthspan and the very real possibility of extending lifespan in the coming decade.
We met in 2009 and he encouraged me to write collaborative journal articles (metabolic winter hypothesis and oxidative priority) and now that work ultimately is the basis for our book, The Healthspan Solution, which focuses more on what we can achieve with diet. It’s been an honor working with him and having a man of his insight as a mentor and friend.
The breakthroughs they are making now is astounding, and the speed they are occuring is dramatic.
But that is just the tip of the iceberg once he (and others) convince the policy makers to treat aging as a disease and fund the research. It has the potential to stop nearly all chronic disease, so the efforts should be increased 1000x times, or more.
I believe this will happen soon, and this book may be a significant factor in the dawning of a new era for humankind.
Dr Sinclair is a visionary with the ability to truly change the world.
* longer healthy lifespan improves all of our lives, not just personally, but for all of the people we love
* mechanisms to increase lifespan are part of our cells and often just need to be activated
* increasing healthy lifespan will not make the world overcrowded, but will benefit everyone by increasing productivity and overall well-being
All of these are well-supported and convincing, including touching and memorable personal experiences.
I do have one major issue, though. Our current medical system is focused on the bottom line, making money is more important than the best protocol. Look at Vioxx, for example, which killed thousands of people so that Merck could make more money. David has personal experiences with the system: his Mom almost died from poisoning by prescription medicine, and his daughter could have died from a serious Lyme infection that was not properly handled.
Yet David accepts that vaccination is a medical miracle, without doing any research on its risks and benefits. I hope he will take a serious look at all the issues:
* the extremely high rates of chronic illness in vaccinated vs non-vaccinated children, The Children’s Health Defense has a good series based on peer-reviewed research
* the connection between aluminum and autism, with artists having the highest levels. See Dr Chris Exley’s peer-reviewed work. Most vaccines have high levels of aluminum that has been shown to stay in the body and migrate to the brain
* the connection between vaccination-induced brain inflammation and brain injury, see vaccine papers dot org, which includes full-text copies of peer-reviewed research: "powerful scientific evidence has emerged indicating that vaccines cause brain injury such as autism, epilepsy, schizophrenia, depression, attention-deficit disorder and other mental illnesses. This scientific evidence has been largely ignored by the media, and by medical institutions that are supposedly guided by science."
* the actual history of vaccination. Medical historians estimate that ALL of modern medicine, including vaccination and antibiotics, reduced childhood mortality by 4-6%. That is, 94-96% of the reduction was from improved sanitation and nutrition. For example, scarlet fever has been eradicated — without any vaccine. A good source is the book Dissolving Illusions.
* the actual contents of vaccines as analyzed by Corvelva, showing high levels of contamination
* the lack of liability for vaccines by the medical industry. Instead, a government fund compensates injuries, and has paid out over $4 billion. This does not motivate safer vaccines!
This book is highly recommended, I am reading it now, very slowly to glean all I can, I have been waiting for this book's release for 6 months, finally the day has arrived.
Top international reviews
I think a typical scientist would and should stop right there; for science does not concern itself with morality but with pure knowledge whether constructive or destructive. Nonetheless, Dr Sinclair goes on to debate the real and political consequences of people living, if not forever, certainly much longer than they do now. To me, this is where the book rapidly goes down hill. Dr Sinclair knows there will be serious repercussions: an increase in population; a greater demand for resources; more pollution; more carbon emissions; etc, etc. He says that alongside the big increase in population in the 1800's was a huge increase in the standard of sanitation and health as though it were causative - more people lead to more benefits. He thinks that GMO and foods modified by other technologies will provide the solution to feeding the ever-increasing numbers of mouths and gets irritated when some people have the temerity to question their safety. Also, because he would be content to work doing his interesting research in his lab for the next 50 years, it does not mean a miner would like to spend another 50 digging coal.
Despite Dr Sinclair's faith in the ingenuity of man, there are times when i sense he is trying to convince himself of his utopian vision rather than the reader. Living to infinity is not the be all and end all; living a healthy life is more important, whether one lives to 70 or 90.
At some point I will re-read the first half of the book - which I enjoyed - but not the second. I must be only part Luddite.
The book is broken into three parts - past, present and future - but in truth it’s science in the first two parts, whilst the final part is futurology, plus the authors obvious passion for what’s possible and his frustrations for human nature.
On the science it was an easy read, I was glued and had my paper and pencil making notes; of which there were many. Fascinating.
In the final third I lost interest, though I finished it. Despite the possibilities outlined being exciting, he went off a bit too far and predicting the future is always a dangerous art that few get right.
If you want to cut straight to his advice, it’s page 304.
But it’s a much a better read to understand the why. If you want other accessible ways to hear the good doctors message, I’d recommend his two interviews on Rich Roll podcast.
If you found this review helpful, give it a thumbs up, makes writing it worthwhile.
Richard Dawkins touched on why we would inherit genes that fail as we age: essentially we reproduce before we suffer from these age-related ailments, and so natural selection has not filtered it out as it presumably has young man/woman ailments that would kill off the would-be reproducer.
The book uses scientific terms and explanations and so some reading on physiology may be beneficial alongside this book. Note taking is a must if you're wanting to retain and be able to explain the contents.
The reason I've given it 3 out of 5 stars is the completely lack of concern over the animals the author and his colleagues tested on. I know its commonplace (though this doesn't make it right) but there is not even any acknowledgement from the author that this is cruel behaviour. He will talk about how he'll age mice prematurely (yes fascinating but cruel), starve them, dissect them prior to natural death, etc. He does comment on how easy it is to buy mice to test on, though. Well, as long as subjecting unlucky animals to torture is convenient!
1. be in calorie restriction / deficit - always, or most of the times
2. practice intermittent fasting
3. focus on eating plant based wholefoods (this is a more general precept that many now espouse)
4. move, excercise, focus on HIIT to increase heart rate and stress the body / system
5. expose yourself to cold temperature to stress your body
also learnt about NMN and how it helps boost NAD+ and encourage sirtuins to prevent cellular degeneration.
ETA: I wrote this review when I was half way through the book, fully expecting the last section to be about various techniques that we can use now to delay aging. However, it turned into a political rant of sorts, and provided no information other than one third of a page describing what he does himself. This came with a disclaimer and really didn't provide anything that anyone who is a member of Longecity or reads Josh Mitteldorf's blog wouldn't know. Hmm. Because of this, I have knocked off a star. This said, please do not let this review sway you not to read the book. Dr. Sinclair is one of the finest researchers of our time and well worth reading and listening to. Check out his interviews online.
Basically, it puts forwards a disease model of aging. This is a controversial and certainly a lot of people would not agree with it, but the evidence is reviewed in a scientific manner which I found quite compelling. However, I would say the narrative goes considerably beyond the evidence, and states things as fact which are yet to be established. The problem is that as yet there are no examples of individuals adding huge amounts of years to their lives, and it will take a long time to generate the kind of evidence required for that.
So although I enjoyed this book immensely, and the author is a published scientist rather than a journalist (or an influencer), I am deducting one star from the rating because I do not think we quite have the evidence base to back up some of the claims made. I also found the book trailed off badly as it went on, where the author started speculating about the social and political impact of increased life spans which of course may not happen. No problem with a little bit of this, but it takes up most of the second half of the book, which was far too much and I found it a bit of a slog to get to the end. Like one of the other reviewers, I will most likely re-read the first half, but definitely not the second.
This is a gamechanger.