Okay, some of the stuff they use for plot points takes some 'talking points' from things that are in the headlines of news stories and such, which is kind of cool, to be on top of current events and work them into the storyline, but some of them are really a stretch for believability. Some of the mental disorders he knows about are... well, they're real, but the way they're used in the story are not the way they really happen.
Thinking about the one episode when the girl came back from war and she was unable to talk, but he found that, just because of a certain droop to her face, she could sing! Wow! Yeah, not buying it. Yes, the condition is real (yes, I looked it up--I'm one of 'THOSE' people) but it wouldn't manifest in such a way that he'd be able to tell just by looking at her face.
This was just one example. It's not that the conditions shown are not real, they are... but the way he is able to 'diagnose' them and tell that this is what someone is suffering from an using that to solve crimes just takes a stretch for me to believe.
However, for the sake of wanting to be entertained, I sometimes allow myself to watch the show without yelling at the television, "Oh, come on!" (Okay, so I don't manage to do that, but at least when I'm yelling at the TV, my family is laughing at me while we watch the show.)
So if you can get past the suspension of disbelief issues, Eric McCormack's performance is really quite brilliant. He plays 'crazy' quite well, and unlike some of his post-Will & Grace work, this one seems really suited to his character as an actor--he just plays this part well, and believable in the struggles that a man, a brilliant man, can be limited by but not stopped by his psychological conditions. Knowing a real-life paranoid schizophrenic, I know he's certainly not as functional as the doctor on this show, but I think they write it and he acts well enough to suspend my disbelief on that. Not all schizophrenics are the same, and some are higher functioning than others.
I like the added element of a love interest in this season, and the conflict with the love interest compared to the fictional person in his mind... it will be interesting to see where this goes.
The acting is... well, a little uncomfortable yet, but I'm getting used to the characters as they get used to each other. Overall, this is a good series that I hope to stick with. Looking forward to season 3.