This film starts by /clearly/ stating it is set four years after the prior film.
The Alice clones attack on The Umbrella Corporation promised in the prior film then occurs.
This doesn't actually work very well, and Alice is injected with the antidote, reducing her from superhero to human again.
She meets her friends, one of whom is wearing a control device, and clearly states it's been 18 months since they parted.
This eventually leads to their boarding a ship which turns out to be Yet Another Evil Lair. However, they manage to take it over just before being assaulted by ... well, you can imagine who, there's only one Evil Corporation, after all.
Note the discrepancy between "four years" and "18 months". Clearly, we have changed time-lines.
But that doesn't much matter -- this is an action flick, and a good one!