Siddhartha Mukherjee

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About Siddhartha Mukherjee
Siddhartha Mukherjee is a cancer physician and researcher. He is an assistant professor of medicine at Columbia University and a staff cancer physician at the CU/NYU Presbytarian Hospital. A former Rhodes scholar, he graduated from Stanford University, University of Oxford (where he received a PhD studying cancer-causing viruses) and from Harvard Medical School. His laboratory focuses on discovering new cancer drugs using innovative biological methods. Mukherjee trained in cancer medicine at the Dana Farber Cancer Institute of Harvard Medical School and was on the staff at the Massachusetts General Hospital. He has published articles and commentary in such journals as Nature, New England Journal of Medicine, Neuron and the Journal of Clinical Investigation and in publications such as the New York Times and the New Republic. His work was nominated for Best American Science Writing, 2000 (edited by James Gleick). He lives in Boston and New York with his wife, Sarah Sze, an artist, and with his daughter, Leela.
His author website is www.siddharthamukherjee.me
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Titles By Siddhartha Mukherjee
Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.
The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.
Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
The basis for the PBS Ken Burns Documentary The Gene: An Intimate History
From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle).
"Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." –Ken Burns
“Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
“Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.
“A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
Over a decade ago, when Siddhartha Mukherjee was a young, exhausted, and isolated medical resident, he discovered a book that would forever change the way he understood the medical profession. The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a “science”? Sciences must have laws—statements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences?
Dr. Mukherjee has spent his career pondering this question—a question that would ultimately produce some of most serious thinking he would do around the tenets of his discipline—culminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine.
Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka! moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee’s signature eloquence and passionate prose, The Laws of Medicine is a critical read, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.
Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christened them “cells”.
The discovery of cells—and the reframing of the human body as a cellular ecosystem—announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer’s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia—all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies.
In The Song of the Cell, Mukherjee tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. He seduces you with writing so vivid, lucid, and suspenseful that complex science becomes thrilling. Told in six parts, laced with Mukherjee’s own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate—a masterpiece.
En 2010, siete millones de personas murieron de cáncer en todo el mundo. Con esta fría estadística Siddhartha Mukherjee, médico e investigador oncológico, arranca su amplia y absorbente «biografía» de una de las enfermedades más extendidas de nuestro tiempo.
El emperador de todos los males es una crónica completa del cáncer desde sus orígenes hasta los modernos tratamientos (quimioterapia de diversos tipos, radioterapia y cirugía, además de la prevención) que han surgido gracias a un siglo de investigación, ensayos y pequeños avances trascendentales en muchos lugares distintos.
Este libro es un repaso a la ciencia del cáncer y a la historia de los tratamientos que le han hecho frente, pero también es una reflexión sobre la enfermedad, la ética médica y las complejas y entrelazadas vidas de los oncólogos y sus pacientes. La empatía que muestra Mukherjee hacia los enfermos de cáncer y sus familias, así como hacia los médicos que muy a menudo tan pocas esperanzas les pueden ofrecer, hacen de este libro una historia llena de humanidad de una enfermedad compleja e inasible.
Reseñas:
«Esta obra debería valer a Mukherjee un merecido lugar en el panteón de los grandes divulgadores de nuestra era, junto a Carl Sagan, Stephen Jay Gould y Stephen Hawking.»
The Boston Globe
«Una magistral historia de la investigación sobre el cáncer.»
Publishers Weekly
Magnífico, necesario y absorbente, Siddhartha Mukherjee, ganador del Premio Pulitzer por El emperador de todos los males, ha escrito una extraordinaria «biografía» del gen y una respuesta a una de las cuestiones más relevantes del futuro: ¿Qué significa ser humano cuando se es capaz de manipular la información genética?
La historia de cómo hemos descifrado el código fuente que nos hace humanos abarca todo el planeta y varios siglos -y probablemente defina el futuro que nos espera.
Entrelazando ciencia, historia y vivencias personales, Mukherjee hace un recorrido por el nacimiento, el crecimiento, la influencia y el futuro de una de las ideas más poderosas y peligrosas de la historia de la ciencia: el gen, la unidad fundamental de la herencia, y la unidad básica de toda la información biológica. Desde Aristóteles y Pitágoras, pasando por los descubrimientos relegados de Mendel, la revolución de Darwin, Watson y Franklin, hasta los avances más innovadores llevados a cabo en nuestro siglo, este libro nos recuerda cómo la genética nos afecta a todos cada día.
Reseñas:
«Esta quizá sea la mejor historia de suspense jamás contada, una búsqueda de milenios dirigida por mil exploradores, de Aristóteles a Mendel a Francis Collins, tras el enigma en el centro de cada célula. Como El emperador de todos los males, El gen es prodigiosa, torrencial y finalmente transcendente. Si te interesa en qué consiste ser humano hoy y en todos los mañanas que vengan, tienes que leer este libro.»
Anthony Doerr, autor de La luz que no puedes ver
«El gen es una magnífica síntesis de la ciencia de la vida, y nos obliga a enfrentarnos con el núcleo de esa ciencia, así como con los retos éticos y filosóficos a nuestra idea de en qué consiste ser humano.»
Paul Berg, Premio Nobel de Química
«Magnífico... La historia del gen se ha contado por trozos de distintas maneras, pero nunca con la perspectiva y la grandeza que Mukherjee aporta a su historia.»
James Gleick, New York Times Book Review
L'imperatore del male è la storia dell'epica lotta contro il cancro. La cronaca degli sforzi per debellare una malattia antica - un tempo clandestina, quasi da non nominare - che oggi è un'entità multiforme, pervasa di una profonda valenza metaforica, medica, scientifica e politica. Questa «biografia» vuole comprenderne la personalità e demistificarne il comportamento per capire se sia possibile sradicarla per sempre dai nostri corpi e dalla nostra società.
Premio Pulitzer nel 2011, L'imperatore del male è un libro rigoroso, animato dalla scrittura ammaliante e dalla tensione narrativa di un autore straordinario, ma anche dalla pietas di un grande medico. Nato come diario di un anno in ospedale, racconta di vittorie e sconfitte, di offensive seguite da altre offensive, di eroismo e superbia, di spirito di sopravvivenza e capacità di recupero; e, inevitabilmente, dei feriti, dei condannati, dei dimenticati, dei caduti.
Gli straordinari progressi fatti dalla genetica negli ultimi decenni aprono insperate ed entusiasmanti possibilità di sconfiggere malattie ritenute finora invincibili, ma al contempo sollevano cruciali interrogativi di carattere etico cui è quasi impossibile sottrarsi, soprattutto perché riguardano l'immediato futuro dell'umanità. Che ne sarà, infatti, dell'essere umano quando avremo imparato a «leggere» e a «scrivere» il suo patrimonio genetico? E, magari, a duplicarlo?
Siddhartha Mukherjee, noto ricercatore oncologo e autore dell'Imperatore del male, impareggiabile «biografia» del cancro, ripercorre le tappe più significative del cammino che ha portato a identificare l'origine di quei caratteri che, pur accomunando ciascun individuo a tutti gli altri membri della sua stessa specie, lo rendono assolutamente unico e irripetibile.
Da Aristotele a Pitagora, da Darwin a Mendel, da Boveri e Morgan a Crick, Watson e Franklin, fino agli scienziati del XXI secolo che sono riusciti a compiere il decisivo passo di mappare il genoma umano, Il gene esamina le innumerevoli ipotesi che si sono succedute nel corso dei secoli, i successi e i fallimenti che hanno costellato il tentativo di comprendere e spiegare i meccanismi dell'ereditarietà e le loro sorprendenti influenze sulla personalità e il destino degli esseri umani. Senza tacere delle agghiaccianti derive dell'eugenetica, non solo a opera dei medici nazisti, né di argomenti di scottante attualità come le possibili implicazioni delle terapie geniche o dell'impiego delle cellule staminali.
Prendendo le mosse dalla sua vicenda familiare, segnata da una dolorosa storia di malattia mentale, e intrecciando scienza, filosofia e letteratura, l'autore racconta in un linguaggio semplice ma rigoroso tutte le peripezie della nascita e dello sviluppo di un'idea scientifica, e offre un salutare spunto di riflessione rispetto ai dubbi che talvolta sorgono quando, uscendo dal laboratorio, le conquiste dell'indagine scientifica entrano con prepotenza nella vita delle persone, promettendo - o rischiando - di cambiarla per sempre.
Die Geschichte einer der mächtigsten und gefährlichsten Ideen der Menschheit
Mukherjee kreiert ein ambitioniertes und faszinierendes Panorama über den Versuch, das menschliche Genom zu entschlüsseln und in unser Erbgut einzugreifen. Es beginnt in einem augustinischen Kloster im Jahr 1856 und führt uns von Darwins Evolutionstheorie über die grausame Eugenik der Nationalsozialisten ins heute und darüber hinaus. Indem er seine eigene Familiengeschichte einwebt, die von tragischen psychischen Erkrankungen geprägt ist, führt Mukherjee uns vor Augen, dass die Forschungsergebnisse aus dem Labor einen immensen Einfluss auf unser echtes Leben haben, auf die Zukunft und die Identätit unserer Kinder.
Das Gen ist das ultimative Buch über die Geschichte der Genetik und ermöglicht uns einen ehrlichen und erhellenden Blick in die Vergangenheit und Zukunft der Menschheit.
»Mukherjee verpackt abstrakte, intellektuelle Ideen in emotionale Geschichten.« The Washington Post
»Leicht verständlich und unterhaltsam, aber ohne grobe Vereinfachungen verknüpft er geschickt große Ereignisse der Wissenschaft mit seiner eigenen Familiengeschichte.« Deutschlandfunk
»Eine grandiose Kulturgeschichte des Krebses.« SPIEGEL
Krebs ist ein Überlebenskünstler: Er verändert sich, er passt sich an, er entwickelt sich weiter, er wächst. Er ist uns biologisch so nahe, dass wir uns oft selbst zerstören, wenn wir ihn vernichten. Die Suche nach der »Heilung« von Krebs hat sich allmählich zum Maßstab unseres wissenschaftlichen und medizinischen Fortschritts entwickelt.
In seinem bahnbrechenden und preisgekrönten Buch erzählt der renommierte Onkologe Siddhartha Mukherjee die faszinierende Geschichte der Beziehung zwischen Mensch und Krebs. Wie haben wir ihn uns in der Vergangenheit vorgestellt? Was konnten wir ihm entgegensetzen? Wo stehen wir jetzt im Kampf gegen diese gefräßigste aller Krankheiten? Mukherjee zeigt, wie weit wir bei der Lösung eines der großen Rätsel der Wissenschaft gekommen sind, und gibt einen faszinierenden Ausblick auf unsere zukünftigen Fortschritte.
»Eine brillante Kombination aus Medizin-Krimi und Kriegsgeschichte. Ein Jahrhundertbuch.« STERN
»Ein ganz wunderbares Buch. Nicht nur, weil es so spannend, so elegant, so ungeheuer reich an Wissen ist. Sondern vor allem, weil es auch von der Hoffnung erzählt.« WAMS
En un recorregut per tot el planeta que abraça uns quants segles, El gen relata la recerca per desxifrar el codi principal que ens conforma i ens defineix com a humans, que determina com som per fora i per dintre.
La història del gen comença en una retirada abadia agustina de Moràvia l'any 1856, quan un monjo concep la possible existència d'una «unitat hereditària». Enllaça amb la teoria de l'evolució de Darwin, i topa amb els horrors de l'eugenèsia nazi de la dècada del 1940. El gen transforma la biologia de postguerra. Reconfigura la nostra percepció de la sexualitat, el caràcter, la capacitat d'elecció i el lliure arbitri. Per sobre de tot, però, aquesta història és filla de l'enginy humà i d'uns esperits obsessius com Charles Darwin, Gregor Mendel, Francis Crick, James Watson o Rosalind Franklin, i de milers de científics que continuen investigant per comprendre el codi més important de tots els codis.
Aquest relat espectacular i emotiu sobre un supòsit científic que acaba cobrant vida és obra de l'autor de The Emperor of All Maladies, un dels grans llibres divulgatius que s'han escrit sobre el càncer. Entrellaçada amb la trama de El gen, però, com un fil vermell, hi ha també una història íntima: la història de la família de Mukherjee i el seu patró recurrent de trastorns mentals, que ens recorda que la genètica té una importància transcendental en la vida quotidiana de tothom. Aquestes qüestions esdevenen encara més vibrants i peremptòries avui dia, en què estem aprenent a «llegir» i a «escriure» el genoma humà, amb totes les possibilitats que comporta de modificar el destí i la identitat dels nostres infants.
El gen, amb una noble ambició i una honestedat incorruptible, ens proporciona un relat insuperable sobre la unitat fonamental de l'herència i un panorama tant del passat com del futur de la humanitat.
Què n'han dit:
«Excepcional. Segurament un dels llibres de ciència més captivadors, potents i elegants que es pugui llegir.»
The Times
«Segurament es tracta de la història de detectius més important de tots els temps: una recerca de milers d'anys feta per una infinitat d'exploradors, des d'Aristòtil a Collins passant per Mendel, per mirar de descobrir els interrogants que hi ha al cor de totes les cèl·lules. El gen és un llibre prodigiós, de gran envergadura, absolutament cabdal. Tothom qui estigui interessat a saber què significa -i que significarà en el futur- ser humà, necessita llegir aquest llibre.»
Anthony Doerr, Premi Pulitzer 2015
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