This is basically an animate comic book. It seems strange that it is not based, at least directly, on a comic book, but it definitely has that feel; no doubt in part due to the influence of Blade, which IS based on a comic book. There is also some obvious imitation of The Matrix, and one scene is a total ripoff of Terminator 2.
My first real objection is that if this is supposed to be science fiction instead of supernatural horror, it needs to play by the rules of science. No virus can make one able to break Newton's Laws of Motion, for example, or can allow one to defy the Conservation of Energy. Magic, I don't know, but viruses certainly cannot do that.
Secondly, there needs to be some sort of rule about how much damage a monster can take before dying. I mean a rule better than plot convenience. In this movie, a hail of bullets can definitely kill a vampire or a werewolf, but only if the monster is a minor character. For the heroes and the end bosses, that rule does not apply.