If you love the dynamics between women who have nothing in common on the surface but are sister in their hearts you will love Three Sisters. Andi, a pediatrician, was left at the alter after a 10 year relationship, Boston, an artist, is suffering from the loss of a child and Deanne,a full time mother and part time craft store employee, is seeing her family move move away from her. Andi comes to Blackberry Island to open her own pediatrics clinic in one of the Three Sisters, a trio of Victorian houses. Her house, along with her life, needs a total rehab. While Boston's house is restored to a funky, artistic version of a Victorian she is dealing with artist block. Deanne's house is perfect but can anything truly be perfect? See how these three woman come together in friendship to help each other overcome obstacles they never thought they would deal with.